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At the highest dose of 12 mg retatrutide, the average weight loss after 48 weeks was 24.2% with reduction up to 30% from the baseline weight in 25% of participants

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The drug undergoes general peptide catabolism through endogenous proteases, distributed across multiple tissues, with no intact liraglutide excreted renally or fecally as a primary elimination route [1]

During **deep slow-wave sleep, brain cells temporarily shrink, allowing cerebrospinal fluid to flow more freely and wash away waste products, including amyloid-beta, a protein linked to Alzheimer's disease